Mike and Sully work to treat a typhus epidemic at Black Kettle's camp, which begins after Mike and Sully unwittingly convince Black Kettle to accept government blankets infected with the virus. Mike is heartbroken and guilt-ridden as she battles the tribe's typhus epidemic. When Matthew comes down with typhus, the town panics and locks the children in the clinic alone with Horace. Colleen treats Matthew and Horace contrives to send the kids out to the reservation to be with Mike. Meanwhile, the town prepares for the Fourth of July, ironically missing the point entirely that the first Americans, the Indians, are being systematically wiped out and further, that the newest Americans, the Immigrants, have just had their camp destroyed by the typhus-fearing townsfolk
