Season 18 Details Casts Episode Lists of Season 18 Title Season 18 Genres Talk Comedy Air Date 2011-01-03 Episode Runtime 01 Hours 03 Minutes Season Number 18 Episode Count On Season 18 181 Production Companies Worldwide Pants, CBS Entertainment Productions, CBS Productions, CBS Studios David Letterman Self - Host Paul Shaffer Self -Musical Director Alan Kalter Self - Announcer (voice) Episode 1 2011-01-03 Brian Williams, Paula Abd... Episode 2 2011-01-04 Tim McGraw, Shaquille O'N... Episode 3 2011-01-05 Jennifer Connelly, Dr. Oz... Episode 4 2011-01-06 Seth Rogen, Beau Garrett,... Episode 5 2011-01-07 Regis Philbin, Hannibal B... Episode 6 2011-01-10 Bill Cosby, a Top Ten Lis... Episode 7 2011-01-11 Vince Vaughn, Mike Wolfe ... Episode 8 2011-01-12 Kevin James, Olivia Munn,... Episode 9 2011-01-13 Kelsey Grammer, Amar'e St... Episode 10 2011-01-14 Joan Rivers, Jeff Caldwel... Episode 11 2011-01-17 Jack Hanna, Steven Tyler... Episode 12 2011-01-18 Betty White, Kim & Kourtn... Episode 13 2011-01-19 Martin Short, Greta Gerwi... Episode 14 2011-01-20 Kaley Cuoco, Piers Morgan... Episode 15 2011-01-21 Nathan Lane, Mike Palasca... Episode 16 2011-01-31 Justin Bieber, Pauley Per... Episode 17 2011-02-01 Matthew Perry, Chris Elli... Episode 18 2011-02-02 Kate Walsh, Jim Gaffigan,... Episode 19 2011-02-03 Howard Stern, Naughty By ... Episode 20 2011-02-04 Martha Stewart, Top Ten w... Episode 21 2011-02-07 Super Bowl MVP Aaron Rodg... Episode 22 2011-02-08 Adam Sandler, Chris Colfe... Episode 23 2011-02-09 Anderson Cooper, Elton Jo... Episode 24 2011-02-10 Nicole "Snooki" Polizzi, ... Episode 25 2011-02-11 Ed Helms, Ted Alexandro, ... Episode 26 2011-02-14 S.I. Swimsuit Cover Revea... Episode 27 2011-02-15 Forest Whitaker, S.I. Swi... Episode 28 2011-02-16 Bill Hader, Grocery Baggi... Episode 29 2011-02-17 Paris Hilton, Nathan Fill... Episode 30 2011-02-18 David Spade, Andy Kindler... Episode 31 2011-02-21 Donald Rumsfeld, Cobie Sm... Episode 32 2011-02-22 Amy Poehler, Jean Chu and... Episode 33 2011-02-23 Rainn Wilson, Hank Aaron... Episode 34 2011-02-24 Senator Rand Paul, Bright... Episode 35 2011-02-25 Matthew Morrison, Jeff Al... Episode 36 2011-02-28 Brian Williams, Trey Park... Episode 37 2011-03-01 Amanda Seyfried, B.J. Nov... Episode 38 2011-03-02 Donald Trump, Vanessa Hud... Episode 39 2011-03-03 Robin Williams, Judy Gree... Episode 40 2011-03-14 Charles Barkley, Sarah Vo... Episode 41 2011-03-15 Bradley Cooper, Mindy Kal... Episode 42 2011-03-16 Steve Martin, Selena Gome... Episode 43 2011-03-21 Dana Carvey, Dr. Michio K... Episode 44 2011-03-22 Katie Couric, The Pains o... Episode 45 2011-03-23 Ben Stiller, Dario Franch... Episode 46 2011-03-28 "Jungle" Jack Hanna, Dann... Episode 47 2011-03-29 Regis Philbin, Snoop Dogg... Episode 48 2011-03-30 Norm Macdonald, CC Sabath... Episode 49 2011-03-31 Chris Rock, Ellen Page, F... Episode 50 2011-04-01 James Franco, Royal Bangs... Episode 51 2011-04-05 Jennifer Garner, Jamie Ol... Episode 52 2011-04-06 Don Rickles, Eva Longoria... Episode 53 2011-04-11 Alec Baldwin, Wiz Khalifa... Episode 54 2011-04-12 Ricky Gervais, Top Ten wi... Episode 55 2011-04-13 Courteney Cox, Aziz Ansar... Episode 56 2011-04-14 Seth Meyers, Carmelo Anth... Episode 57 2011-04-15 Tina Fey, Tommy Johnagin,... Episode 58 2011-04-25 Bill Maher, Cote de Pablo... Episode 59 2011-04-26 Will Ferrell, The Twiligh... Episode 60 2011-04-27 Kate Hudson, Rich Eisen, ... Episode 61 2011-04-28 Dr. Phil McGraw, Chris He... Episode 62 2011-04-29 John Krasinski, Brian Kil... Episode 63 2011-05-02 Brian Williams, Rex Ryan... Episode 64 2011-05-03 Caroline Kennedy, Ty Burr... Episode 65 2011-05-04 Betty White, Rick Harriso... Episode 66 2011-05-05 Jodie Foster, Tom Dreesen... Episode 67 2011-05-06 Bill Murray, ''The Human ... Episode 68 2011-05-09 Albert Brooks, Kristen Wi... Episode 69 2011-05-10 Mark Harmon, Chris Morgan... Episode 71 2011-05-12 Stupid human tricks, Jim ... Episode 72 2011-05-13 Joan Rivers, Nick Griffin... Episode 73 2011-05-16 Julianna Margulies, Andy ... Episode 74 2011-05-17 Martin Short, Melissa McC... Episode 75 2011-05-18 Keith Olbermann, Julie Bo... Episode 76 2011-05-19 Kelly Ripa, Jennifer Lawr... Episode 77 2011-05-20 Tracy Morgan, Jake Johann... Episode 78 2011-05-23 Lady Gaga, Eric Stonestre... Episode 79 2011-05-24 Ewan McGregor, Scott Pell... Episode 80 2011-05-25 Piedmont Bird Callers, Ke... Episode 81 2011-05-26 Ray Romano, Reese Waters,... Episode 82 2011-06-06 Meredith Vieira, Indianap... Episode 83 2011-06-07 Kyle Chandler, Kathy Grif... Episode 84 2011-06-08 Jon Cryer, Rachel Maddow,... Episode 85 2011-06-09 Neil Patrick Harris, Mike... Episode 86 2011-06-13 Adm. Michael Mullen, Top ... Episode 87 2011-06-14 Ryan Reynolds, chef Eric ... Episode 88 2011-06-15 Jim Carrey, Rosie Hunting... Episode 89 2011-06-16 Samuel L. Jackson, Texas ... Episode 90 2011-06-20 Cameron Diaz, Eddie Vedde... Episode 91 2011-06-21 Jason Bateman, Amy Sedari... Episode 92 2011-06-22 Kevin James, pet fashion ... Episode 93 2011-06-23 Jason Segel, horse whispe... Episode 94 2011-06-27 Shia LaBeouf, Bert Kreisc... Episode 95 2011-06-28 Tom Hanks, Sleepy Man Ban... Episode 96 2011-06-29 Patrick Dempsey, Erica Hi... Episode 97 2011-06-30 Julia Roberts, Cake... Episode 98 2011-07-11 Emma Watson, George Lopez... Episode 99 2011-07-12 Roseanne Barr, Tom Felton... Episode 100 2011-07-13 Ryan Gosling, Gomez... Episode 101 2011-07-14 Kyra Sedgwick, Tim Harmst... Episode 102 2011-07-18 Bono & the Edge, a perfor... Episode 103 2011-07-19 Steve Carell, Hope Solo a... Episode 104 2011-07-20 Jeremy Piven, Captain Lui... Episode 105 2011-07-21 Harrison Ford, Porcelain ... Episode 106 2011-07-25 Brian Williams, Tim Robbi... Episode 107 2011-07-26 Julianne Moore, Johnny Ga... Episode 108 2011-07-27 Craig Ferguson, Connie Br... Episode 109 2011-07-28 Kirstie Alley, Louis C.K.... Episode 110 2011-08-01 James Franco, Dianna Agro... Episode 111 2011-08-02 Ricky Gervais, Cat Deeley... Episode 112 2011-08-03 Emma Stone, Alan Mulally,... Episode 113 2011-08-04 Colin Farrell, Christophe... Episode 114 2011-08-22 Denis Leary, Elizabeth Co... Episode 115 2011-08-23 Rachel Maddow, Rose Byrne... Episode 116 2011-08-24 Ashton Kutcher, Rafael Na... Episode 117 2011-08-25 Paul Rudd, Bill Burr, Den... Episode 118 2011-08-29 Jason Sudeikis, Bettina L... Episode 119 2011-08-30 Alec Baldwin, Joe Namath,... Episode 120 2011-08-31 David Arquette, Aubrey Pl... Episode 121 2011-09-01 Julianna Margulies, Joe W... Episode 122 2011-09-06 Kim, Kourtney & Khloe Kar... Episode 123 2011-09-07 Sgt. 1st Class Leroy Petr... Episode 124 2011-09-08 Michael J. Fox, Top Ten b... Episode 125 2011-09-19 Dr. Jill Biden, Ted Danso... Episode 126 2011-09-20 Jonah Hill, Paula Abdul, ... Episode 127 2011-09-21 Taylor Lautner, Minka Kel... Episode 128 2011-09-22 Sergeant Dakota Meyer, So... Episode 129 2011-09-23 Nathan Fillion, Larry Mil... Episode 130 2011-09-26 Seth Rogen, Poppy Montgom... Episode 131 2011-09-27 Jack Hanna, Anna Faris... Episode 132 2011-09-28 Anderson Cooper, Nick Off... Episode 133 2011-09-29 Kaley Cuoco, Skipper Bivi... Episode 134 2011-09-30 Samuel L. Jackson, Karen ... Episode 135 2011-10-03 Brian Williams, Sting... Episode 136 2011-10-04 Hugh Jackman, Sean Young,... Episode 137 2011-10-05 George Clooney, Mastodon... Episode 138 2011-10-06 Caroline Kennedy, dock di... Episode 139 2011-10-07 Bryan Cranston, Jeff Altm... Episode 140 2011-10-10 Tracy Morgan, Mike Golic ... Episode 141 2011-10-11 Matthew Broderick, horse ... Episode 142 2011-10-12 Bill Clinton, Deer Tick... Episode 143 2011-10-13 Bill O'Reilly, Martina Mc... Episode 144 2011-10-14 Artie Lange, Eddie Brill,... Episode 145 2011-10-24 Salma Hayek, Keith Olberm... Episode 146 2011-10-25 Eddie Murphy, Jane Levy, ... Episode 147 2011-10-26 Justin Timberlake, Jennif... Episode 148 2011-10-27 Johnny Depp, Foster the P... Episode 149 2011-10-28 Tom Brokaw, Myq Kaplan, T... Episode 150 2011-10-31 Tony La Russa, Jesse Eise... Episode 151 2011-11-01 Ben Stiller, Whitney Cumm... Episode 152 2011-11-02 Condoleezza Rice... Episode 153 2011-11-03 Mark Harmon, Mike Judge, ... Episode 154 2011-11-04 Bill Cosby, Jason Isbell ... Episode 155 2011-11-07 Melissa McCarthy, Anthony... Episode 156 2011-11-08 Robert Pattinson, Annie L... Episode 157 2011-11-09 Adam Sandler, Peter Gabri... Episode 158 2011-11-10 Stupid Humans Tricks, Kat... Episode 159 2011-11-11 Steve Martin, Felicity Jo... Episode 160 2011-11-14 Jason Segel, Jamie Oliver... Episode 161 2011-11-15 Bill Maher, Nikki Reed, F... Episode 162 2011-11-16 Jerry Seinfeld, Lykke Li... Episode 163 2011-11-17 Regis Philbin, John Foger... Episode 164 2011-11-18 Herman Cain, Grouplove... Episode 165 2011-11-21 Andy Kindler, Ty Burrell,... Episode 166 2011-11-22 Amy Sedaris, Christopher ... Episode 167 2011-11-23 Justin Bieber, Brian Rega... Episode 168 2011-12-05 Jonah Hill, Kristen Johns... Episode 169 2011-12-06 Matt Damon, Shelby Lynne... Episode 170 2011-12-07 Jessica Biel, Tom Dreesen... Episode 171 2011-12-08 Charlize Theron, Kevin Ne... Episode 172 2011-12-09 David Duchovny, Comedian ... Episode 173 2011-12-12 Scarlett Johansson, Julie... Episode 174 2011-12-13 Barbara Walters, Bill Had... Episode 175 2011-12-14 Robert Downey Jr., Rooney... Episode 176 2011-12-15 Tom Hanks, My Morning Jac... Episode 177 2011-12-16 Jude Law, Bob Sarlatte, G... Episode 178 2011-12-19 Tom Cruise, Anthony Hamil... Episode 179 2011-12-20 Harry Connick Jr., Scott ... Episode 180 2011-12-21 Jon Huntsman, J. Cole... Episode 181 2011-12-22 Anderson Cooper, Lindsey ... Episode 182 2011-12-23 Jay Thomas, David Hyde Pi...
